Holmes cites this interview with Blaine as the most awkward moment of his professional career and one of TV's bloopers when he refused to speak and gave him the "evil eye".
In 1993, Holmes started working at GMTV, hosting the first show on 1 January 1993 with Anne Davies.
He initially hosted the show with Lorna Dunkley between October 2005 and January 2007, then with Charlotte Hawkins from 2007 to 2014.
Hawkins defected to ITV in March 2014 and was replaced by Isabel Webster.
In 2014, Holmes and Ruth Langsford co-hosted a 10-part ITV daytime game show, Gift Wrapped.
In 2015, Holmes and Langsford presented a six-part factual series for Channel 5 entitled Eamonn & Ruth: How the Other Half Lives. Finally, on 19 December 2013, to celebrate the end of Millionaire on ITV, Holmes re-appeared on the show with Alex Ferguson.